Curcumin

Curcuma longa ist eine blühende Pflanze aus der Ingwerfamilie, die am besten als Kurkuma bekannt ist, ein Gewürz, das in Curry verwendet wird. Es ist ein Polyphenol mit entzündungshemmenden Eigenschaften und der Fähigkeit, die Menge an Antioxidantien, die der Körper produziert, zu erhöhen. Kurkumin und die in Kurkuma vorkommenden Curcuminoide können extrahiert werden, um Nahrungsergänzungsmittel mit einer viel höheren Potenz als Kurkuma zu erzeugen. Allerdings wird oral eingenommenes Kurkumin während der Verdauung schlecht aufgenommen, sodass eine Vielzahl von Formulierungen entwickelt wurde, um die Bioverfügbarkeit zu verbessern.

Hauptvorteile: Die Supplementierung mit Curcumin senkt zuverlässig einige Marker der Entzündung\[\text{1}\]\[\text{2}\]\[\text{3}\] und erhöht die Spiegel der endogenen Antioxidantien im Körper\[\text{4}\]\[\text{5}\]\[\text{2}\]. Allerdings hat Curcumin einen minimalen Effekt auf Marker der Entzündung bei Menschen mit chronischen Entzündungskrankheiten\[\text{6}\]. Weitere Forschung ist in vielen Bereichen der Gesundheit zu Curcumin notwendig, aber die aktuellen Beweise zeigen kleine bis moderate Verbesserungen der Symptome von Depressionen\[\text{7}\]\[\text{8}\]\[\text{9}\] und moderate bis große Verbesserungen in Schmerz und Funktion bei Arthrose\[\text{10}\]\[\text{11}\]\[\text{12}\]\[\text{13}\]\[\text{14}\]. Curcumin zeigt auch vielversprechende Ansätze für die Behandlung einer Art von entzündlicher Darmerkrankung namens Colitis ulcerosa\[\text{15}\]\[\text{16}\]\[\text{17}\], aber weitere Forschung ist notwendig, um die optimale Dosis und Verabreichungsart zu klären. Verbesserungen bei Blutlipiden\[\text{18}\]\[\text{19}\]\[\text{20}\]\[\text{21}\]\[\text{22}\]\[\text{23}\]\[\text{24}\]\[\text{25}\], Markern der glykämischen Kontrolle\[\text{26}\]\[\text{19}\]\[\text{21}\]\[\text{22}\]\[\text{23}\], Blutdruck\[\text{19}\]\[\text{27}\], Leberenzymen\[\text{28}\]\[\text{29}\]\[\text{30}\]\[\text{31}\] und Gewichtsverlust\[\text{32}\]\[\text{33}\]\[\text{34}\]\[\text{35}\]\[\text{36}\]\[\text{37}\] wurden ebenfalls nach der Supplementierung mit Curcumin beobachtet. Allerdings sind die Forschungsergebnisse zu diesen Ergebnissen manchmal inkonsistent, und es sind weitere hochwertige randomisierte kontrollierte Studien erforderlich, um endgültige Schlussfolgerungen zu ziehen.

Eine der größten Nachteile von Curcumin ist, dass es bei oraler Einnahme allein nur schlecht absorbiert wird.\[1\] Dosierungen von bis zu 8 Gramm pro Tag von Curcuminoiden wurden nicht mit ernsthaften unerwünschten Effekten bei Menschen in Verbindung gebracht.\[2\] Um diese Abwesenheit von Nebenwirkungen zu bestätigen, sind jedoch umfassende Langzeitstudien erforderlich. Studien, die hohe Dosen von Curcumin verwendeten, berichteten über einige milde unerwünschte Effekte, darunter Übelkeit, Durchfall, Kopfschmerzen, Hautausschlag und gelben Stuhl.\[3\][4\][5\] Die Verwendung von Curcumin mit Piperin (einem Extrakt aus schwarzem Pfeffer) kann die unerwünschten Reaktionen auf Curcumin erhöhen, da Piperin die intestinalen Permeabilität stark erhöht.\[6\] Nicht alle Formulierungen von Curcumin wurden in gleichem Maße auf Sicherheit getestet.

Die potenziell vorteilhaften Wirkungen von Curcumin scheinen größtenteils das Ergebnis seiner entzündungshemmenden und antioxidativen Eigenschaften zu sein.\[1\]\[2\] Diese Eigenschaften werden durch die direkte oder indirekte Wechselwirkung von Curcumin mit, und Modulation von, verschiedenen molekularen Zielen vermittelt, einschließlich Transkriptionsfaktoren, Enzymen, Zellzyklusproteinen, Rezeptoren, Zelloberflächenadhäsionsmolekülen, Wachstumsfaktoren und Proteinkinase.\[3\]\[4\]

Pain Hidayat R, Parlindungan F, Nisa JI, Mahendra AI, Indika MI, Efendi CEfficacy of Curcuma longa in relieving pain symptoms of knee osteoarthritis patients: a systematic review and meta analysis of clinical trials.J Rheum Dis.(2025 Jan 1)
Pain Srivastava S, Saksena AK, Khattri S, Kumar S, Dagur RSCurcuma longa extract reduces inflammatory and oxidative stress biomarkers in osteoarthritis of knee: a four month, double blind, randomized, placebo controlled trialInflammopharmacology.(2016 Dec)
Pain Haroyan A, Mukuchyan V, Mkrtchyan N, Minasyan N, Gasparyan S, Sargsyan A, Narimanyan M, Hovhannisyan AEfficacy and safety of curcumin and its combination with boswellic acid in osteoarthritis: a comparative, randomized, double blind, placebo controlled studyBMC Complement Altern Med.(2018 Jan 9)
Pain Nakagawa Y, Mukai S, Yamada S, Matsuoka M, Tarumi E, Hashimoto T, Tamura C, Imaizumi A, Nishihira J, Nakamura TShort term effects of highly bioavailable curcumin for treating knee osteoarthritis: a randomized, double blind, placebo controlled prospective studyJ Orthop Sci.(2014 Nov)
Pain Shep D, Khanwelkar C, Gade P, Karad SSafety and efficacy of curcumin versus diclofenac in knee osteoarthritis: a randomized open label parallel arm studyTrials.(2019 Apr 11)
Pain Panahi Y, Rahimnia AR, Sharafi M, Alishiri G, Saburi A, Sahebkar ACurcuminoid treatment for knee osteoarthritis: a randomized double blind placebo controlled trialPhytother Res.(2014 Nov)
Pain Madhu K, Chanda K, Saji MJSafety and efficacy of Curcuma longa extract in the treatment of painful knee osteoarthritis: a randomized placebo controlled trialInflammopharmacology.(2013 Apr)
Pain Belcaro G, Cesarone MR, Dugall M, Pellegrini L, Ledda A, Grossi MG, Togni S, Appendino GEfficacy and safety of Meriva®, a curcumin phosphatidylcholine complex, during extended administration in osteoarthritis patientsAltern Med Rev.(2010 Dec)
Pain Kuptniratsaikul V, Dajpratham P, Taechaarpornkul W, Buntragulpoontawee M, Lukkanapichonchut P, Chootip C, Saengsuwan J, Tantayakom K, Laongpech SEfficacy and safety of Curcuma domestica extracts compared with ibuprofen in patients with knee osteoarthritis: a multicenter studyClin Interv Aging.(2014 Mar 20)
Pain Belcaro G, Cesarone MR, Dugall M, Pellegrini L, Ledda A, Grossi MG, Togni S, Appendino GProduct evaluation registry of Meriva®, a curcumin phosphatidylcholine complex, for the complementary management of osteoarthritisPanminerva Med.(2010 Jun)
Pain Pinsornsak P, Niempoog SThe efficacy of Curcuma Longa L. extract as an adjuvant therapy in primary knee osteoarthritis: a randomized control trialJ Med Assoc Thai.(2012 Jan)
Pain Panda SK, Nirvanashetty S, Parachur VA, Mohanty N, Swain TA Randomized, Double Blind, Placebo Controlled, Parallel Group Study to Evaluate the Safety and Efficacy of Curene® versus Placebo in Reducing Symptoms of Knee OABiomed Res Int.(2018 Oct 25)
Osteoarthritis Symptoms Vilai Kuptniratsaikul, Sunee Thanakhumtorn, Pornsiri Chinswangwatanakul, Luksamee Wattanamongkonsil, Visanu ThamlikitkulEfficacy and safety of Curcuma domestica extracts in patients with knee osteoarthritisJ Altern Complement Med.(2009 Aug)
Osteoarthritis Symptoms Henrotin et alBio optimized Curcuma longa extract is efficient on knee osteoarthritis pain: a double blind multicenter randomized placebo controlled three arm studyArthritis Res Ther.()
Interleukin 1 beta Hsueh HC, Ho GR, Tzeng SI, Liang KH, Horng YSEffects of curcumin on serum inflammatory biomarkers in patients with knee osteoarthritis: a systematic review and meta analysis of randomized controlled trials.BMC Complement Med Ther.(2025 Jul 4)
Uric Acid Panahi Y, Kianpour P, Mohtashami R, Jafari R, Simental Mendía LE, Sahebkar ACurcumin Lowers Serum Lipids and Uric Acid in Subjects With Nonalcoholic Fatty Liver Disease: A Randomized Controlled TrialJ Cardiovasc Pharmacol.(2016 Sep)
Blood glucose Cicero AFG, Sahebkar A, Fogacci F, Bove M, Giovannini M, Borghi CEffects of phytosomal curcumin on anthropometric parameters, insulin resistance, cortisolemia and non alcoholic fatty liver disease indices: a double blind, placebo controlled clinical trialEur J Nutr.(2019 Feb 22)
Blood glucose Jazayeri Tehrani SA, Rezayat SM, Mansouri S, Qorbani M, Alavian SM, Daneshi Maskooni M, Hosseinzadeh Attar MJNano curcumin improves glucose indices, lipids, inflammation, and Nesfatin in overweight and obese patients with non alcoholic fatty liver disease (NAFLD): a double blind randomized placebo controlled clinical trialNutr Metab (Lond).(2019 Jan 28)
Blood glucose Saeede Saadati, Behzad Hatami, Zahra Yari, Mohammad Amin Shahrbaf, Sareh Eghtesad, Asieh Mansour, Hossein Poustchi, Mehdi Hedayati, Morteza Aghajanpoor Pasha, Amir Sadeghi, Azita HekmatdoostThe effects of curcumin supplementation on liver enzymes, lipid profile, glucose homeostasis, and hepatic steatosis and fibrosis in patients with non alcoholic fatty liver diseaseEur J Clin Nutr.(2019 Mar)
Blood glucose Navekar R, Rafraf M, Ghaffari A, Asghari Jafarabadi M, Khoshbaten MTurmeric Supplementation Improves Serum Glucose Indices and Leptin Levels in Patients with Nonalcoholic Fatty Liver DiseasesJ Am Coll Nutr.(2017 May Jun)
Low density lipoprotein (LDL) Rahmani S, Asgary S, Askari G, Keshvari M, Hatamipour M, Feizi A, Sahebkar ATreatment of Non alcoholic Fatty Liver Disease with Curcumin: A Randomized Placebo controlled TrialPhytother Res.(2016 Sep)
Low density lipoprotein (LDL) Kailin Yang, Junpeng Chen, Tianqing Zhang, Xiao Yuan, Anqi Ge, Shanshan Wang, Hao Xu, Liuting Zeng, Jinwen GeEfficacy and safety of dietary polyphenol supplementation in the treatment of non alcoholic fatty liver disease: A systematic review and meta analysisFront Immunol.(2022 Sep 9)
Liver Enzymes M H Ngu, M N Norhayati, Z Rosnani, M M ZulkifliCurcumin as adjuvant treatment in patients with non alcoholic fatty liver (NAFLD) disease: A systematic review and meta analysisComplement Ther Med.(2022 Sep)
Weight Jafarirad S, Mansoori A, Adineh A, Panahi Y, Hadi A, Goodarzi RDoes Turmeric/curcumin Supplementation Change Anthropometric Indices in Patients with Non alcoholic Fatty Liver Disease? A Systematic Review and Meta analysis of Randomized Controlled Trials.Clin Nutr Res.(2019 Jul)
Insulin Kocher A, Bohnert L, Schiborr C, Frank JHighly bioavailable micellar curcuminoids accumulate in blood, are safe and do not reduce blood lipids and inflammation markers in moderately hyperlipidemic individualsMol Nutr Food Res.(2016 Jul)
Insulin Maithili Karpaga Selvi N, Sridhar MG, Swaminathan RP, Sripradha REfficacy of Turmeric as Adjuvant Therapy in Type 2 Diabetic PatientsIndian J Clin Biochem.(2015 Apr)
Total cholesterol Dehzad MJ, Ghalandari H, Amini MR, Askarpour MEffects of curcumin/turmeric supplementation on lipid profile: A GRADE assessed systematic review and dose response meta analysis of randomized controlled trials.Complement Ther Med.(2023 Aug)
Total cholesterol Ferguson JJA, Wolska A, Remaley AT, Stojanovski E, MacDonald Wicks L, Garg MLBread enriched with phytosterols with or without curcumin modulates lipoprotein profiles in hypercholesterolaemic individuals. A randomised controlled trialFood Funct.(2019 May 22)
Total cholesterol Mirzabeigi P, Mohammadpour AH, Salarifar M, Gholami K, Mojtahedzadeh M, Javadi MRThe Effect of Curcumin on some of Traditional and Non traditional Cardiovascular Risk Factors: A Pilot Randomized, Double blind, Placebo controlled TrialIran J Pharm Res.(2015 Spring)
Uric Acid Pannipa Bupparenoo, Rattapol Pakchotanon, Pongthorn Narongroeknawin, Paijit Asavatanabodee, Sumapa ChaiamnuayEffect of Curcumin on Serum Urate in Asymptomatic Hyperuricemia: A Randomized Placebo Controlled TrialJ Diet Suppl.(2021)
Blood glucose Adab Z, Eghtesadi S, Vafa MR, Heydari I, Shojaii A, Haqqani H, Arablou T, Eghtesadi MEffect of turmeric on glycemic status, lipid profile, hs CRP, and total antioxidant capacity in hyperlipidemic type 2 diabetes mellitus patientsPhytother Res.(2019 Apr)
Blood glucose Funamoto M, Sunagawa Y, Katanasaka Y, Miyazaki Y, Imaizumi A, Kakeya H, Yamakage H, Satoh Asahara N, Komiyama M, Wada H, Hasegawa KHighly absorptive curcumin reduces serum atherosclerotic low density lipoprotein levels in patients with mild COPDInt J Chron Obstruct Pulmon Dis.(2016 Aug 26)
Blood glucose Ferguson JJA, Stojanovski E, MacDonald Wicks L, Garg MLCurcumin potentiates cholesterol lowering effects of phytosterols in hypercholesterolaemic individuals. A randomised controlled trialMetabolism.(2018 May)
Triglycerides Panahi Y, Khalili N, Sahebi E, Namazi S, Reiner Ž, Majeed M, Sahebkar ACurcuminoids modify lipid profile in type 2 diabetes mellitus: A randomized controlled trialComplement Ther Med.(2017 Aug)
Triglycerides DiSilvestro RA, Joseph E, Zhao S, Bomser JDiverse effects of a low dose supplement of lipidated curcumin in healthy middle aged peopleNutr J.(2012 Sep 26)
Triglycerides Mohammadi A, Sahebkar A, Iranshahi M, Amini M, Khojasteh R, Ghayour Mobarhan M, Ferns GAEffects of supplementation with curcuminoids on dyslipidemia in obese patients: a randomized crossover trialPhytother Res.(2013 Mar)
Low density lipoprotein (LDL) Baum L, Cheung SK, Mok VC, Lam LC, Leung VP, Hui E, Ng CC, Chow M, Ho PC, Lam S, Woo J, Chiu HF, Goggins W, Zee B, Wong A, Mok H, Cheng WK, Fong C, Lee JS, Chan MH, Szeto S, Lui VWCurcumin effects on blood lipid profile in a 6 month human studyPharmacol Res.(2007 Dec)
Blood glucose Rahimi HR, Mohammadpour AH, Dastani M, Jaafari MR, Abnous K, Ghayour Mobarhan M, Kazemi Oskuee RThe effect of nano curcumin on HbA1c, fasting blood glucose, and lipid profile in diabetic subjects: a randomized clinical trialAvicenna J Phytomed.(2016 Sep Oct)
Blood glucose Panahi Y, Khalili N, Sahebi E, Namazi S, Simental Mendía LE, Majeed M, Sahebkar AEffects of Curcuminoids Plus Piperine on Glycemic, Hepatic and Inflammatory Biomarkers in Patients with Type 2 Diabetes Mellitus: A Randomized Double Blind Placebo Controlled TrialDrug Res (Stuttg).(2018 Jul)
Blood glucose Yang H, Xu W, Zhou Z, Liu J, Li X, Chen L, Weng J, Yu ZCurcumin attenuates urinary excretion of albumin in type II diabetic patients with enhancing nuclear factor erythroid derived 2 like 2 (Nrf2) system and repressing inflammatory signaling efficaciesExp Clin Endocrinol Diabetes.(2015 Jun)
Blood glucose Adibian M, Hodaei H, Nikpayam O, Sohrab G, Hekmatdoost A, Hedayati MThe effects of curcumin supplementation on high sensitivity C reactive protein, serum adiponectin, and lipid profile in patients with type 2 diabetes: A randomized, double blind, placebo controlled trialPhytother Res.(2019 May)
Blood glucose Chuengsamarn S, Rattanamongkolgul S, Phonrat B, Tungtrongchitr R, Jirawatnotai SReduction of atherogenic risk in patients with type 2 diabetes by curcuminoid extract: a randomized controlled trialJ Nutr Biochem.(2014 Feb)
Blood glucose Na LX, Li Y, Pan HZ, Zhou XL, Sun DJ, Meng M, Li XX, Sun CHCurcuminoids exert glucose lowering effect in type 2 diabetes by decreasing serum free fatty acids: a double blind, placebo controlled trialMol Nutr Food Res.(2013 Sep)
Blood glucose Asadi S, Gholami MS, Siassi F, Qorbani M, Khamoshian K, Sotoudeh GNano curcumin supplementation reduced the severity of diabetic sensorimotor polyneuropathy in patients with type 2 diabetes mellitus: A randomized double blind placebo controlled clinical trialComplement Ther Med.(2019 Apr)
Blood glucose Chuengsamarn S, Rattanamongkolgul S, Luechapudiporn R, Phisalaphong C, Jirawatnotai SCurcumin extract for prevention of type 2 diabetesDiabetes Care.(2012 Nov)
Oxidative Stress Biomarkers Tabrizi R, Vakili S, Akbari M, Mirhosseini N, Lankarani KB, Rahimi M, Mobini M, Jafarnejad S, Vahedpoor Z, Asemi ZThe effects of curcumin containing supplements on biomarkers of inflammation and oxidative stress: A systematic review and meta analysis of randomized controlled trials.Phytother Res.(2019 Feb)
Blood glucose Jafari A, Abbastabar M, Alaghi A, Heshmati J, Crowe FL, Sepidarkish MCurcumin on Human Health: A Comprehensive Systematic Review and Meta Analysis of 103 Randomized Controlled Trials.Phytother Res.(2024 Dec)
Blood glucose Thota RN, Dias CB, Abbott KA, Acharya SH, Garg MLCurcumin alleviates postprandial glycaemic response in healthy subjects: A cross over, randomized controlled studySci Rep.(2018 Sep 12)
Blood glucose Wickenberg J, Ingemansson SL, Hlebowicz JEffects of Curcuma longa (turmeric) on postprandial plasma glucose and insulin in healthy subjectsNutr J.(2010 Oct 12)
Blood glucose Jin D, Jin S, Sheng G, Cui Z, Gao P, Li GEffects of Curcumin on Postmenopausal Women\s Health: A Systematic Review and Meta Analysis.Phytother Res.(2025 May)
Blood glucose Wan S, Luo J, Zhu Y, An P, Luo Y, Xing QThe Effect of Antioxidant Polyphenol Supplementation on Cardiometabolic Risk Factors: A Systematic Review and Meta Analysis.Nutrients.(2024 Dec 5)
Triglycerides Kanit Pungcharoenkul, Phensri ThongnopnuaEffect of different curcuminoid supplement dosages on total in vivo antioxidant capacity and cholesterol levels of healthy human subjectsPhytother Res.(2011 Nov)
Arterial Stiffness Santos Parker JR, Strahler TR, Bassett CJ, Bispham NZ, Chonchol MB, Seals DRCurcumin supplementation improves vascular endothelial function in healthy middle aged and older adults by increasing nitric oxide bioavailability and reducing oxidative stressAging (Albany NY).(2017 Jan 3)
Prostate Specific Antigen Ide H, Tokiwa S, Sakamaki K, Nishio K, Isotani S, Muto S, Hama T, Masuda H, Horie SCombined inhibitory effects of soy isoflavones and curcumin on the production of prostate specific antigenProstate.(2010 Jul 1)
Iron Absorption Siriporn Tuntipopipat, Kunchit Judprasong, Christophe Zeder, Emorn Wasantwisut, Pattanee Winichagoon, Somsri Charoenkiatkul, Richard Hurrell, Thomas WalczykChili, but not turmeric, inhibits iron absorption in young women from an iron fortified composite mealJ Nutr.(2006 Dec)
Weight Unhapipatpong C, Polruang N, Shantavasinkul PC, Julanon N, Numthavaj P, Thakkinstian AThe effect of curcumin supplementation on weight loss and anthropometric indices: an umbrella review and updated meta analyses of randomized controlled trials.Am J Clin Nutr.(2023 May)
Triglycerides Akazawa N, Choi Y, Miyaki A, Tanabe Y, Sugawara J, Ajisaka R, Maeda SCurcumin ingestion and exercise training improve vascular endothelial function in postmenopausal womenNutr Res.(2012 Oct)
Blood Pressure Sugawara J, Akazawa N, Miyaki A, Choi Y, Tanabe Y, Imai T, Maeda SEffect of endurance exercise training and curcumin intake on central arterial hemodynamics in postmenopausal women: pilot studyAm J Hypertens.(2012 Jun)
Triglycerides Usharani P, Mateen AA, Naidu MU, Raju YS, Chandra NEffect of NCB 02, atorvastatin and placebo on endothelial function, oxidative stress and inflammatory markers in patients with type 2 diabetes mellitus: a randomized, parallel group, placebo controlled, 8 week studyDrugs R D.(2008)
Blood Pressure Barber Chamoux N, Milenkovic D, Verny MA, Habauzit V, Pereira B, Lambert C, Richard D, Boby C, Mazur A, Lusson JR, Dubray C, Morand CSubstantial Variability Across Individuals in the Vascular and Nutrigenomic Response to an Acute Intake of Curcumin: A Randomized Controlled TrialMol Nutr Food Res.(2018 Mar)
Blood Flow Oliver JM, Stoner L, Rowlands DS, Caldwell AR, Sanders E, Kreutzer A, Mitchell JB, Purpura M, Jäger RNovel Form of Curcumin Improves Endothelial Function in Young, Healthy Individuals: A Double Blind Placebo Controlled StudyJ Nutr Metab.(2016)
Depression Symptoms Lopresti AL, Drummond PDEfficacy of curcumin, and a saffron/curcumin combination for the treatment of major depression: A randomised, double blind, placebo controlled studyJ Affect Disord.(2017 Jan 1)
Depression Symptoms Lopresti AL, Maes M, Maker GL, Hood SD, Drummond PDCurcumin for the treatment of major depression: a randomised, double blind, placebo controlled studyJ Affect Disord.(2014)
Depression Symptoms Yu JJ, Pei LB, Zhang Y, Wen ZY, Yang JLChronic Supplementation of Curcumin Enhances the Efficacy of Antidepressants in Major Depressive Disorder: A Randomized, Double Blind, Placebo Controlled Pilot StudyJ Clin Psychopharmacol.(2015 Aug)
Depression Symptoms Bergman J, Miodownik C, Bersudsky Y, Sokolik S, Lerner PP, Kreinin A, Polakiewicz J, Lerner VCurcumin as an add on to antidepressive treatment: a randomized, double blind, placebo controlled, pilot clinical studyClin Neuropharmacol.(2013 May Jun)
Depression Symptoms Kanchanatawan B, Tangwongchai S, Sughondhabhirom A, Suppapitiporn S, Hemrunrojn S, Carvalho AF, Maes MAdd on Treatment with Curcumin Has Antidepressive Effects in Thai Patients with Major Depression: Results of a Randomized Double Blind Placebo Controlled StudyNeurotox Res.(2018 Apr)
Total cholesterol Kim SW, Ha KC, Choi EK, Jung SY, Kim MG, Kwon DY, Yang HJ, Kim MJ, Kang HJ, Back HI, Kim SY, Park SH, Baek HY, Kim YJ, Lee JY, Chae SWThe effectiveness of fermented turmeric powder in subjects with elevated alanine transaminase levels: a randomised controlled studyBMC Complement Altern Med.(2013 Mar 8)
Liver Enzymes Dehzad MJ, Ghalandari H, Amini MR, Askarpour MEffects of curcumin/turmeric supplementation on liver function in adults: A GRADE assessed systematic review and dose response meta analysis of randomized controlled trials.Complement Ther Med.(2023 Jun)
PMS Symptoms Khayat S, Fanaei H, Kheirkhah M, Moghadam ZB, Kasaeian A, Javadimehr MCurcumin attenuates severity of premenstrual syndrome symptoms: A randomized, double blind, placebo controlled trialComplement Ther Med.(2015 Jun)
Weight Akbari M, Lankarani KB, Tabrizi R, Ghayour Mobarhan M, Peymani P, Ferns G, Ghaderi A, Asemi ZThe Effects of Curcumin on Weight Loss Among Patients With Metabolic Syndrome and Related Disorders: A Systematic Review and Meta Analysis of Randomized Controlled Trials.Front Pharmacol.(2019)
Weight Amin F, Islam N, Anila N, Gilani AHClinical efficacy of the co administration of Turmeric and Black seeds (Kalongi) in metabolic syndrome a double blind randomized controlled trial TAK MetS trialComplement Ther Med.(2015 Apr)
Oxidative Stress Biomarkers Panahi Y, Hosseini MS, Khalili N, Naimi E, Majeed M, Sahebkar AAntioxidant and anti inflammatory effects of curcuminoid piperine combination in subjects with metabolic syndrome: A randomized controlled trial and an updated meta analysisClin Nutr.(2015 Dec)
Triglycerides Wilar G, Suhandi C, Fukunaga K, Shigeno M, Kawahata I, Abdulah R, Sasaki TEffects of Nanocurcumin Supplementation on Metabolic Syndrome: A Systematic Review and Meta Analysis of Randomized Controlled Trials.Pharmacol Res.(2025 Jan 31)
Triglycerides Panahi Y, Khalili N, Hosseini MS, Abbasinazari M, Sahebkar ALipid modifying effects of adjunctive therapy with curcuminoids piperine combination in patients with metabolic syndrome: results of a randomized controlled trialComplement Ther Med.(2014 Oct)
Bilirubin Amalraj A, Varma K, Jacob J, Divya C, Kunnumakkara AB, Stohs SJ, Gopi SA Novel Highly Bioavailable Curcumin Formulation Improves Symptoms and Diagnostic Indicators in Rheumatoid Arthritis Patients: A Randomized, Double Blind, Placebo Controlled, Two Dose, Three Arm, and Parallel Group StudyJ Med Food.(2017 Oct)
Rheumatoid Arthritis Symptoms Chandran B, Goel AA randomized, pilot study to assess the efficacy and safety of curcumin in patients with active rheumatoid arthritisPhytother Res.(2012 Nov)
Adiponectin Campbell MS, Ouyang A, I M K, Charnigo RJ, Westgate PM, Fleenor BSInfluence of enhanced bioavailable curcumin on obesity associated cardiovascular disease risk factors and arterial function: A double blinded, randomized, controlled trialNutrition.(2019 Jun)
C Reactive Protein (CRP) Nieman DC, Cialdella Kam L, Knab AM, Shanely RAInfluence of red pepper spice and turmeric on inflammation and oxidative stress biomarkers in overweight females: a metabolomics approachPlant Foods Hum Nutr.(2012 Dec)
Depression Symptoms Esmaily H, Sahebkar A, Iranshahi M, Ganjali S, Mohammadi A, Ferns G, Ghayour Mobarhan MAn investigation of the effects of curcumin on anxiety and depression in obese individuals: A randomized controlled trialChin J Integr Med.(2015 May)
Depression Symptoms Panahi Y, Badeli R, Karami GR, Sahebkar AInvestigation of the efficacy of adjunctive therapy with bioavailability boosted curcuminoids in major depressive disorderPhytother Res.(2015 Jan)
Depression Symptoms Sanmukhani J, Satodia V, Trivedi J, Patel T, Tiwari D, Panchal B, Goel A, Tripathi CBEfficacy and safety of curcumin in major depressive disorder: a randomized controlled trialPhytother Res.(2014 Apr)
Erections Choi YH, Han DH, Kim SW, Kim MJ, Sung HH, Jeon HG, Jeong BC, Seo SI, Jeon SS, Lee HM, Choi HYA randomized, double blind, placebo controlled trial to evaluate the role of curcumin in prostate cancer patients with intermittent androgen deprivationProstate.(2019 May)
Inflammation Khajehdehi P, Pakfetrat M, Javidnia K, Azad F, Malekmakan L, Nasab MH, Dehghanzadeh GOral supplementation of turmeric attenuates proteinuria, transforming growth factor ? and interleukin 8 levels in patients with overt type 2 diabetic nephropathy: a randomized, double blind and placebo controlled studyScand J Urol Nephrol.(2011 Nov)
Leg Edema Appendino G, Belcaro G, Cornelli U, Luzzi R, Togni S, Dugall M, Cesarone MR, Feragalli B, Ippolito E, Errichi BM, Pellegrini L, Ledda A, Ricci A, Bavera P, Hosoi M, Stuard S, Corsi M, Errichi S, Gizzi GPotential role of curcumin phytosome (Meriva) in controlling the evolution of diabetic microangiopathy. A pilot studyPanminerva Med.(2011 Sep)
Pancreatitis Symptoms Durgaprasad S, Pai CG, Vasanthkumar, Alvres JF, Namitha SA pilot study of the antioxidant effect of curcumin in tropical pancreatitisIndian J Med Res.(2005 Oct)
Fructosamine Thota RN, Acharya SH, Garg MLCurcumin and/or omega 3 polyunsaturated fatty acids supplementation reduces insulin resistance and blood lipids in individuals with high risk of type 2 diabetes: a randomised controlled trialLipids Health Dis.(2019 Jan 26)
Colorectal Cancer Risk He ZY, Shi CB, Wen H, Li FL, Wang BL, Wang JUpregulation of p53 expression in patients with colorectal cancer by administration of curcuminCancer Invest.(2011 Mar)
Colorectal Cancer Risk Robert E Carroll, Richard V Benya, Danielle Kim Turgeon, Shaiju Vareed, Malloree Neuman, Luz Rodriguez, Madhuri Kakarala, Philip M Carpenter, Christine McLaren, Frank L Meyskens Jr, Dean E BrennerPhase IIa clinical trial of curcumin for the prevention of colorectal neoplasiaCancer Prev Res (Phila).(2011 Mar)
Ulcerative Colitis Symptoms Peter R Holt, Seymour Katz, Robert KirshoffCurcumin therapy in inflammatory bowel disease: a pilot studyDig Dis Sci.(2005 Nov)
Ulcerative Colitis Symptoms Mohseni S, Tavakoli A, Ghazipoor H, Pouralimohamadi N, Zare R, Rampp T, Shayesteh M, Pasalar MCurcumin for the clinical treatment of inflammatory bowel diseases: a systematic review and meta analysis of placebo controlled randomized clinical trials.Front Nutr.(2025)
Interleukin 6 T Krishnareddy N, Thomas JV, Nair SS, N Mulakal J, Maliakel BP, Krishnakumar IMA Novel Curcumin Galactomannoside Complex Delivery System Improves Hepatic Function Markers in Chronic Alcoholics: A Double Blinded, randomized, Placebo Controlled StudyBiomed Res Int.(2018 Sep 23)
Inflammation Khajehdehi P, Zanjaninejad B, Aflaki E, Nazarinia M, Azad F, Malekmakan L, Dehghanzadeh GROral supplementation of turmeric decreases proteinuria, hematuria, and systolic blood pressure in patients suffering from relapsing or refractory lupus nephritis: a randomized and placebo controlled studyJ Ren Nutr.(2012 Jan)
Oxidative Stress Biomarkers Biswas J, Sinha D, Mukherjee S, Roy S, Siddiqi M, Roy MCurcumin protects DNA damage in a chronically arsenic exposed population of West BengalHum Exp Toxicol.(2010 Jun)
Oxidative Stress Biomarkers Kalpravidh RW, Siritanaratkul N, Insain P, Charoensakdi R, Panichkul N, Hatairaktham S, Srichairatanakool S, Phisalaphong C, Rachmilewitz E, Fucharoen SImprovement in oxidative stress and antioxidant parameters in beta thalassemia/Hb E patients treated with curcuminoidsClin Biochem.(2010 Mar)
Pain Di Pierro F, Rapacioli G, Di Maio EA, Appendino G, Franceschi F, Togni SComparative evaluation of the pain relieving properties of a lecithinized formulation of curcumin (Meriva(®)), nimesulide, and acetaminophenJ Pain Res.(2013)
Triglycerides Alwi I, Santoso T, Suyono S, Sutrisna B, Suyatna FD, Kresno SB, Ernie SThe effect of curcumin on lipid level in patients with acute coronary syndromeActa Med Indones.(2008 Oct)
Inflammation Hanai H, Iida T, Takeuchi K, Watanabe F, Maruyama Y, Andoh A, Tsujikawa T, Fujiyama Y, Mitsuyama K, Sata M, Yamada M, Iwaoka Y, Kanke K, Hiraishi H, Hirayama K, Arai H, Yoshii S, Uchijima M, Nagata T, Koide YCurcumin maintenance therapy for ulcerative colitis: randomized, multicenter, double blind, placebo controlled trialClin Gastroenterol Hepatol.(2006 Dec)
Stomach Ulcers Koosirirat C, Linpisarn S, Changsom D, Chawansuntati K, Wipasa JInvestigation of the anti inflammatory effect of Curcuma longa in Helicobacter pylori infected patientsInt Immunopharmacol.(2010 Jul)
Mucositis Symptoms Chainani Wu N, Madden E, Lozada Nur F, Silverman S JrHigh dose curcuminoids are efficacious in the reduction in symptoms and signs of oral lichen planusJ Am Acad Dermatol.(2012 May)
Oxidative Stress Biomarkers Baum L, Lam CW, Cheung SK, Kwok T, Lui V, Tsoh J, Lam L, Leung V, Hui E, Ng C, Woo J, Chiu HF, Goggins WB, Zee BC, Cheng KF, Fong CY, Wong A, Mok H, Chow MS, Ho PC, Ip SP, Ho CS, Yu XW, Lai CY, Chan MH, Szeto S, Chan IH, Mok VSix month randomized, placebo controlled, double blind, pilot clinical trial of curcumin in patients with Alzheimer diseaseJ Clin Psychopharmacol.(2008 Feb)
COVID 19 Severity Hamed Valizadeh, Samaneh Abdolmohammadi Vahid, Svetlana Danshina, Mehmet Ziya Gencer, Ali Ammari, Armin Sadeghi, Leila Roshangar, Saeed Aslani, Abdolreza Esmaeilzadeh, Mahnaz Ghaebi, Sepehr Valizadeh, Majid AhmadiNano curcumin therapy, a promising method in modulating inflammatory cytokines in COVID 19 patientsInt Immunopharmacol.(2020 Dec)
Pain Agarwal KA, Tripathi CD, Agarwal BB, Saluja SEfficacy of turmeric (curcumin) in pain and postoperative fatigue after laparoscopic cholecystectomy: a double blind, randomized placebo controlled studySurg Endosc.(2011 Dec)
Intestinal Motility Shimouchi A, Nose K, Takaoka M, Hayashi H, Kondo TEffect of dietary turmeric on breath hydrogenDig Dis Sci.(2009 Aug)
Vascular Function Gimblet CJ, Kruse NT, Geasland K, Michelson J, Sun M, Ten Eyck P, Linkenmeyer C, Mandukhail SR, Rossman MJ, Sambharia M, Chonchol M, Kurella Tamura M, Seals D, Hoth KF, Jalal DCurcumin Supplementation and Vascular and Cognitive Function in Chronic Kidney Disease: A Randomized Controlled Trial.Antioxidants (Basel).(2024 Aug 14)
Creatine Kinase Liu X, Lin L, Hu GMeta analysis of the effect of curcumin supplementation on skeletal muscle damage status.PLoS One.(2024 Jul 15)
Muscle Oxygenation Ramos Junior OJF, Pinheiro VDS, Souza TGDS, Alvares TSEffect of Curcumin Intake on Skeletal Muscle Oxygen Saturation Parameters in Older Participants.Antioxidants (Basel).(2024 Sep 26)
Risk Of Cardiovascular Disease Fogacci F, Avagimyan A, Cesaro A, Bernardi M, Perone F, Giovannini M, Cicero AFGThe effect of highly bioavailable forms of curcumin on lipoprotein(a) plasma levels: A systematic review and meta analysis of randomized clinical studies.Prostaglandins Other Lipid Mediat.(2025 Jun)
Cognition Wang W, Zhao R, Liu B, Li KThe effect of curcumin supplementation on cognitive function: an updated systematic review and meta analysis.Front Nutr.(2025)
Cognition Yu L, Li N, Li B, Ye KX, Guo J, Shan J, Cao L, Song M, Wang Y, Lee TS, Maier AB, Feng LTargeting cognitive aging with curcumin supplementation: A systematic review and meta analysis.J Prev Alzheimers Dis.(2025 Jun 26)
Mucositis Symptoms Amatto PPG, Chaves L, França SC, Carvalho JCT, Carmona F, Pereira AMSEfficacy of different pharmaceutical forms of Curcuma longa or curcumin in reducing oral mucositis severity and incidence in cancer patients: a systematic review and meta analysis.Front Pharmacol.(2025)
Oxidative Stress Biomarkers Yu M, Liu S, Li J, Ni C, Li X, Cui WEfficacy of antioxidant intervention and exercise intervention for lipid peroxidation in dialysis patients: a meta analysis.Front Med (Lausanne).(2025)
Oral Lichen Planus Symptoms Shi W, Wang Q, Jiang S, Wu Y, Li C, Xie Y, Chen Q, Luo XEvaluating the efficacy of curcumin in the management of oral potentially malignant disorders: a systematic review and meta analysis.PeerJ.(2024)
Irritable Bowel Syndrome Symptoms Zeraattalab Motlagh S, Ranjbar M, Mohammadi H, Adibi PNutritional Interventions in Adult Patients With Irritable Bowel Syndrome: An Umbrella Review of Systematic Reviews and Meta analyses of Randomized Clinical Trials.Nutr Rev.(2024 Aug 7)
Liver Fat Huang Q, An Z, Xin X, Gou X, Tian X, Hu Y, Mei Z, Feng QThe Effectiveness of Curcumin, Resveratrol, and Silymarin on MASLD: A Systematic Review and Meta Analysis.Food Sci Nutr.(2024 Dec)
Luteinizing Hormone Mohammadi S, Ziaei S, Morvaridi M, Hasani M, Mirtaheri E, Farsi F, Ebrahimi S, Daneshzad E, Heshmati JImpacts of Curcumin Supplementation on Cardiometabolic Risk Factors in Patients With Polycystic Ovary Syndrome: A Systematic Review and Dose Response Meta Analysis.Health Sci Rep.(2025 Mar)
Luteinizing Hormone Zhao G, Fan Y, Li R, Huang Y, Li W, Zhao Y, Zhou M, He JThe effectiveness of nutritional supplements in improving polycystic ovary syndrome in women: a systematic review and network meta analysis.Reprod Biol Endocrinol.(2025 Jul 3)