Vitamin C

Vitamin C ist ein wasserlösliches, essentielles Vitamin, das in Früchten und Gemüse, insbesondere in Zitrusfrüchten, vorkommt. Der Mensch ist nicht in der Lage, Vitamin C im Körper zu synthetisieren, daher muss es über die Nahrung aufgenommen werden. Vitamin C ist wichtig für die Funktion des Immunsystems und wirkt als starkes Antioxidans. Es fungiert auch als Cofaktor für die Kollagensynthese.

Hauptvorteile.. : Menschen nehmen oft Vitamin C als Ergänzung, wenn sie erkältet sind. Laut verschiedenen Studien kann Vitamin C wirksam die Dauer einer Erkältung verkürzen, scheint jedoch die Häufigkeit von Erkältungen in einer Bevölkerung nicht zu verringern.\[1\]\[2\] Die verfügbare Literatur deutet darauf hin, dass eine Dosis zwischen 200 mg und 2.000 mg vorteilhaft sein könnte, um die Dauer von Erkältungen zu reduzieren. Oft wird Vitamin C wegen seiner antioxidativen Wirkung genutzt und es wurde auf sein mögliches Potenzial bei Alzheimer-Krankheit und Krebs untersucht. Niedrigere Vitamin-C-Spiegel sind bei Menschen mit Alzheimer vorhanden, selbst bei ausreichender Nahrungsaufnahme.\[3\] Man nimmt an, dass oxidativer Stress eine wichtige Rolle bei der Entstehung der Erkrankung spielt, weshalb die antioxidativen Effekte von Vitamin C vorteilhaft sein könnten.\[4\]\[5\] In Tierstudien konnte orales Vitamin C oxidative und entzündliche Biomarker reduzieren.\[6\] In aktuellen Krebsforschungen wurde festgestellt, dass Vitamin C bei hohen Dosen oxidative Stress in Krebszellen fördern kann, was zu zytotoxischen Effekten bei Mäusen führt.\[7\] Obwohl vielversprechend, sind weitere Forschungen und humanmedizinische Studien erforderlich, um die Wirksamkeit zu bestimmen.

Haupternachteile: Im Allgemeinen scheint die Supplementierung mit Vitamin C in empfohlenen Dosen sicher zu sein. Höhere Dosen (3.000–10.000 mg) können jedoch Durchfall verursachen.\[1\] Eine Meta-Analyse stellte ein erhöhtes Risiko für Zahnerosionen bei kautbaren Vitamin C-Tabletten fest.\[2\] Eine seltene, aber bemerkenswerte Möglichkeit einer Nephrotoxizität nach der Verabreichung hoher Dosen wurde ebenfalls beobachtet,\[3\][4\] doch dies ist bei typischer oraler Supplementierung unwahrscheinlich.

Vitamin C fungiert als Cofaktor für verschiedene Enzyme, insbesondere für solche, die an der Kollagensynthese beteiligt sind, und als Antioxidans. Es ist ein essentielles Vitamin, das der Mensch nicht selbst synthetisieren kann, weshalb es durch die Nahrungsaufnahme aufgenommen werden muss. Ein Mangel an diesem Vitamin führt zu Skorbut, einer Krankheit, die durch einen Mangel an Vitamin C verursacht wird.

HbA1c Mason SA, Della Gatta PA, Snow RJ, Russell AP, Wadley GD ascorbic acid supplementation improves skeletal muscle oxidative stress and insulin sensitivity in people with type 2 diabetes: Findings of a randomized controlled study Free Radic Biol Med. (2016 Apr)
HbA1c Siavash M, Amini MVitamin C may have similar beneficial effects to Gemfibrozil on serum high density lipoprotein cholesterol in type 2 diabetic patients J Res Pharm Pract. (2014 Jul)
HbA1c Dakhale GN, Chaudhari HV, Shrivastava MSupplementation of vitamin C reduces blood glucose and improves glycosylated hemoglobin in type 2 diabetes mellitus: a randomized, double blind study Adv Pharmacol Sci. (2011)
HbA1c Bishop N, Schorah CJ, Wales JKThe effect of vitamin C supplementation on diabetic hyperlipidaemia: a double blind, crossover study Diabet Med. (1985 Mar)
HbA1c JAYESH K BHATT, SABIN THOMAS, NANJAN MJEFFECT OF ORAL SUPPLEMENTATION OF VITAMIN C ON GLYCEMIC CONTROL AND LIPID PROFILE IN PATIENTS WITH TYPE 2 DIABETES MELLITUS International Journal of Pharmacy and Pharmaceutical Sciences.()
HbA1c Klein F, Juhl B, Christiansen JSUnchanged renal haemodynamics following high dose ascorbic acid administration in normoalbuminuric IDDM patients Scand J Clin Lab Invest. (1995 Feb)
HbA1c Camargo JL, Stifft J, Gross JLThe effect of aspirin and vitamins C and E on HbA1c assays Clin Chim Acta. (2006 Oct)
HbA1c Mason SA, Rasmussen B, van Loon LJC, Salmon J, Wadley GDAscorbic acid supplementation improves postprandial glycaemic control and blood pressure in individuals with type 2 diabetes: Findings of a randomized cross over trial Diabetes Obes Metab. (2019 Mar)
HbA1c Mahmoudabadi MM, Djalali M, Djazayery SA, Keshavarz SA, Eshraghian MR, Yaraghi AA, Askari G, Ghiasvand R, Zarei MEffects of eicosapentaenoic acid and vitamin C on glycemic indices, blood pressure, and serum lipids in type 2 diabetic Iranian males J Res Med Sci. (2011 Mar)
Triglycerides Ellulu MS, Rahmat A, Patimah I, Khazaai H, Abed YEffect of vitamin C on inflammation and metabolic markers in hypertensive and/or diabetic obese adults: a randomized controlled trial Drug Des Devel Ther. (2015 Jul 1)
Triglycerides Gutierrez AD, Duran Valdez E, Robinson I, de Serna DG, Schade DSDoes short term vitamin C reduce cardiovascular risk in type 2 diabetes? Endocr Pract. (2013 Sep Oct)
Triglycerides Tousoulis D, Antoniades C, Vasiliadou C, Kourtellaris P, Koniari K, Marinou K, Charakida M, Ntarladimas I, Siasos G, Stefanadis CEffects of atorvastatin and vitamin C on forearm hyperaemic blood flow, asymmetrical dimethylarginine levels and the inflammatory process in patients with type 2 diabetes mellitus Heart. (2007 Feb)
Triglycerides Mazloom Z, Hejazi N, Dabbaghmanesh MH, Tabatabaei HR, Ahmadi A, Ansar HEffect of vitamin C supplementation on postprandial oxidative stress and lipid profile in type 2 diabetic patients Pak J Biol Sci. (2011 Oct 1)
Low density lipoprotein (LDL) Ghaffari et alThe effects of vitamin C on diabetic patients Pharm Lett.()
Blood glucose Chen H, Karne RJ, Hall G, Campia U, Panza JA, Cannon RO 3rd, Wang Y, Katz A, Levine M, Quon MJHigh dose oral vitamin C partially replenishes vitamin C levels in patients with Type 2 diabetes and low vitamin C levels but does not improve endothelial dysfunction or insulin resistance Am J Physiol Heart Circ Physiol. (2006 Jan)
HbA1c Ashor AW, Werner AD, Lara J, Willis ND, Mathers JC, Siervo MEffects of vitamin C supplementation on glycaemic control: a systematic review and meta analysis of randomised controlled trials Eur J Clin Nutr. (2017 Dec)
Exercise Induced Oxidation Nakhostin Roohi B, Babaei P, Rahmani Nia F, Bohlooli SEffect of vitamin C supplementation on lipid peroxidation, muscle damage and inflammation after 30 min exercise at 75% VO2max J Sports Med Phys Fitness. (2008 Jun)
Exercise Induced Oxidation Bryant RJ, Ryder J, Martino P, Kim J, Craig BWEffects of vitamin E and C supplementation either alone or in combination on exercise induced lipid peroxidation in trained cyclists J Strength Cond Res. (2003 Nov)
Cortisol Davison G, Gleeson MThe effect of 2 weeks vitamin C supplementation on immunoendocrine responses to 2.5 h cycling exercise in man Eur J Appl Physiol. (2006 Jul)
Cortisol Glen Davison, Michael GleesonInfluence of acute vitamin C and/or carbohydrate ingestion on hormonal, cytokine, and immune responses to prolonged exercise Int J Sport Nutr Exerc Metab. (2005 Oct)
Resistin Bo S, Ciccone G, Durazzo M, Gambino R, Massarenti P, Baldi I, Lezo A, Tiozzo E, Pauletto D, Cassader M, Pagano GEfficacy of antioxidant treatment in reducing resistin serum levels: a randomized study PLoS Clin Trials. (2007 May 4)
Inflammation Colby JA, Chen WT, Baker WL, Coleman CI, Reinhart K, Kluger J, White CMEffect of ascorbic acid on inflammatory markers after cardiothoracic surgery Am J Health Syst Pharm. (2011 Sep 1)
Blood Flow Sergio De Marchi, Manlio Prior, Anna Rigoni, Sara Zecchetto, Fanny Rulfo, Enrico ArosioAscorbic acid prevents vascular dysfunction induced by oral glucose load in healthy subjects Eur J Intern Med. (2012 Jan)
Oxidative Stress Biomarkers Kuiper HC, Bruno RS, Traber MG, Stevens JFVitamin C supplementation lowers urinary levels of 4 hydroperoxy 2 nonenal metabolites in humans Free Radic Biol Med. (2011 Apr 1)
Oxidative Stress Biomarkers Retana Ugalde R, Casanueva E, Altamirano Lozano M, González Torres C, Mendoza Núñez VMHigh dosage of ascorbic acid and alpha tocopherol is not useful for diminishing oxidative stress and DNA damage in healthy elderly adults Ann Nutr Metab. (2008)
Oxidative Stress Biomarkers Johnston CS, Dancho CL, Strong GMOrange juice ingestion and supplemental vitamin C are equally effective at reducing plasma lipid peroxidation in healthy adult women J Am Coll Nutr. (2003 Dec)
C Reactive Protein (CRP) Block G, Jensen CD, Dalvi TB, Norkus EP, Hudes M, Crawford PB, Holland N, Fung EB, Schumacher L, Harmatz PVitamin C treatment reduces elevated C reactive protein Free Radic Biol Med. (2009 Jan 1)
Blood glucose Johnston CS, Yen MFMegadose of vitamin C delays insulin response to a glucose challenge in normoglycemic adults Am J Clin Nutr. (1994 Nov)
Protection from Smoking Fuller CJ, May MA, Martin KJThe effect of vitamin E and vitamin C supplementation on LDL oxidizability and neutrophil respiratory burst in young smokers J Am Coll Nutr. (2000 Jun)
Exercise Adaptations Ristow M, Zarse K, Oberbach A, Klöting N, Birringer M, Kiehntopf M, Stumvoll M, Kahn CR, Blüher MAntioxidants prevent health promoting effects of physical exercise in humans Proc Natl Acad Sci U S A. (2009 May 26)
DNA Damage Guarnieri S, Riso P, Porrini MOrange juice vs vitamin C: effect on hydrogen peroxide induced DNA damage in mononuclear blood cells Br J Nutr. (2007 Apr)
Mineral Bioaccumulation Calabrese EJ, Stoddard A, Leonard DA, Dinardi SRThe effects of vitamin C supplementation on blood and hair levels of cadmium, lead, and mercury Ann N Y Acad Sci. (1987)
Glycemic Control Yfanti C, Nielsen AR, Akerström T, Nielsen S, Rose AJ, Richter EA, Lykkesfeldt J, Fischer CP, Pedersen BKEffect of antioxidant supplementation on insulin sensitivity in response to endurance exercise training Am J Physiol Endocrinol Metab. (2011 May)
Upper Respiratory Tract Infection Symptoms Anderson TW, Reid DB, Beaton GHVitamin C and the common cold: a double blind trial Can Med Assoc J. (1972 Sep 23)
Upper Respiratory Tract Infection Symptoms Charleston SS, Clegg KMAscorbic acid and the common cold Lancet. (1972 Jun 24)
Upper Respiratory Tract Infection Symptoms Van Straten M, Josling PPreventing the common cold with a vitamin C supplement: a double blind, placebo controlled survey Adv Ther. (2002 May Jun)
Upper Respiratory Tract Infection Symptoms Carson M, Cox H, Corbett M, Pollitt NVitamin C and the common cold J Soc Occup Med. (1975 Jul)
Upper Respiratory Tract Infection Symptoms Anderson TW, Beaton GH, Corey P, Spero LWinter illness and vitamin C: the effect of relatively low doses Can Med Assoc J. (1975 Apr 5)
Upper Respiratory Tract Infection Symptoms Karlowski TR, Chalmers TC, Frenkel LD, Kapikian AZ, Lewis TL, Lynch JMAscorbic acid for the common cold. A prophylactic and therapeutic trial JAMA. (1975 Mar 10)
Upper Respiratory Tract Infection Symptoms Dahlberg G, Engel A, Rydin HThe Value of Ascorbic Acid as a Prophylactic against Common Colds Acta Medica Scandinavica.()
Upper Respiratory Tract Infection Symptoms Miller JZ, Nance WE, Norton JA, Wolen RL, Griffith RS, Rose RJTherapeutic effect of vitamin C. A co twin control study JAMA. (1977 Jan 17)
Upper Respiratory Tract Infection Symptoms Himmelstein S, Robergs R, Koehler K, Lewis S, Qualls CVitamin C supplementation and upper respiratory tract infections in marathon runners J Exerc Physiol Online.()
Upper Respiratory Tract Infection Symptoms Sabiston BH, Radomski MWHealth problems and vitamin C in Canadian northern military operations.()
Upper Respiratory Tract Infection Symptoms Elwood PC, Hughes SJ, Leger ASA randomized controlled trial of the therapeutic effect of vitamin C in the common cold Practitioner. (1977 Jan)
Upper Respiratory Tract Infection Symptoms Carr AB, Einstein R, Lai LY, Martin NG, Starmer GAVitamin C and the common cold: a second MZ Cotwin control study Acta Genet Med Gemellol (Roma). (1981)
Upper Respiratory Tract Infection Symptoms Walker GH, Bynoe ML, Tyrrell DATrial of ascorbic acid in prevention of colds Br Med J. (1967 Mar 11)
Upper Respiratory Tract Infection Symptoms Audera C, Patulny RV, Sander BH, Douglas RMMega dose vitamin C in treatment of the common cold: a randomised controlled trial Med J Aust. (2001 Oct 1)
Upper Respiratory Tract Infection Symptoms Lewis TL, Karlowski TR, Kapikian AZ, Lynch JM, Shaffer GW, George DAA controlled clinical trial of ascorbic acid for the common cold Ann N Y Acad Sci. (1975 Sep 30)
Upper Respiratory Tract Infection Symptoms Gorton HC, Jarvis KThe effectiveness of vitamin C in preventing and relieving the symptoms of virus induced respiratory infections J Manipulative Physiol Ther. (1999 Oct)
Upper Respiratory Tract Infection Symptoms Pitt HA, Costrini AMVitamin C prophylaxis in marine recruits JAMA. (1979 Mar 2)
Upper Respiratory Tract Infection Symptoms Clegg KM, Macdonald JML Ascorbic acid and D isoascorbic acid in a common cold survey Am J Clin Nutr. (1975 Sep)
Upper Respiratory Tract Infection Symptoms Elwood PC, Lee HP, St Leger AS, Baird M, Howard A A randomized controlled trial of vitamin C in the prevention and amelioration of the common cold Br J Prev Soc Med. (1976 Sep)
Upper Respiratory Tract Infection Symptoms Schwartz AR, Togo Y, Hornick RB, Tominaga S, Gleckman RAEvaluation of the efficacy of ascorbic acid in prophylaxis of induced rhinovirus 44 infection in man J Infect Dis. (1973 Oct)
Upper Respiratory Tract Infection Symptoms Ludvigsson J, Hansson LO, Tibbling GVitamin C as a preventive medicine against common colds in children Scand J Infect Dis. (1977)
Upper Respiratory Tract Infection Symptoms FRANZ WL, HEYL HL, SANDS GWBlood ascorbic acid level in bioflavonoid and ascorbic acid therapy of common cold J Am Med Assoc. (1956 Nov 24)
Upper Respiratory Tract Infection Symptoms Cowdan D, Diehl H, Baker ABVitamins For The Prevention Of Colds JAMA.()
Upper Respiratory Tract Infection Symptoms Tyrrell DA, Craig JW, Meada TW, White TA trial of ascorbic acid in the treatment of the common cold Br J Prev Soc Med. (1977 Sep)
Common Cold Symptoms Ineffectiveness of vitamin C in treating coryza. Practitioner. (1968 Mar)
Upper Respiratory Tract Infection Risk Kim TK, Lim HR, Byun JSVitamin C supplementation reduces the odds of developing a common cold in Republic of Korea Army recruits: randomised controlled trial BMJ Mil Health. (2020 Mar 5)
Total cholesterol Knab AM, Shanely RA, Henson DA, Jin F, Heinz SA, Austin MD, Nieman DCInfluence of quercetin supplementation on disease risk factors in community dwelling adults J Am Diet Assoc. (2011 Apr)
Interferon Gamma Nieman DC, Henson DA, McAnulty SR, McAnulty L, Swick NS, Utter AC, Vinci DM, Opiela SJ, Morrow JDInfluence of vitamin C supplementation on oxidative and immune changes after an ultramarathon J Appl Physiol (1985). (2002 May)
Cortisol Carrillo AE, Murphy RJ, Cheung SSVitamin C supplementation and salivary immune function following exercise heat stress Int J Sports Physiol Perform. (2008 Dec)
Cortisol Palmer FM, Nieman DC, Henson DA, McAnulty SR, McAnulty L, Swick NS, Utter AC, Vinci DM, Morrow JDInfluence of vitamin C supplementation on oxidative and salivary IgA changes following an ultramarathon Eur J Appl Physiol. (2003 Mar)
Upper Respiratory Tract Infection Risk Baird IM, Hughes RE, Wilson HK, Davies JE, Howard ANThe effects of ascorbic acid and flavonoids on the occurrence of symptoms normally associated with the common cold Am J Clin Nutr. (1979 Aug)
Upper Respiratory Tract Infection Risk Hunt C, Chakravorty NK, Annan GThe clinical and biochemical effects of vitamin C supplementation in short stay hospitalized geriatric patients Int J Vitam Nutr Res. (1984)
Inflammation Thompson D, Bailey DM, Hill J, Hurst T, Powell JR, Williams CProlonged vitamin C supplementation and recovery from eccentric exercise Eur J Appl Physiol. (2004 Jun)
Muscle Damage Bryer SC, Goldfarb AHEffect of high dose vitamin C supplementation on muscle soreness, damage, function, and oxidative stress to eccentric exercise Int J Sport Nutr Exerc Metab. (2006 Jun)
Muscle Damage Theodorou AA, Nikolaidis MG, Paschalis V, Koutsias S, Panayiotou G, Fatouros IG, Koutedakis Y, Jamurtas AZNo effect of antioxidant supplementation on muscle performance and blood redox status adaptations to eccentric training Am J Clin Nutr. (2011 Jun)
Aerobic Exercise Metrics Roberts LA, Beattie K, Close GL, Morton JPVitamin C consumption does not impair training induced improvements in exercise performance Int J Sports Physiol Perform. (2011 Mar)
Aerobic Exercise Metrics Ataka S, Tanaka M, Nozaki S, Mizuma H, Mizuno K, Tahara T, Sugino T, Shirai T, Kajimoto Y, Kuratsune H, Kajimoto O, Watanabe YEffects of Applephenon and ascorbic acid on physical fatigue Nutrition. (2007 May)
Upper Respiratory Tract Infection Symptoms Constantini NW, Dubnov Raz G, Eyal BB, Berry EM, Cohen AH, Hemilä HThe effect of vitamin C on upper respiratory infections in adolescent swimmers: a randomized trial Eur J Pediatr. (2011 Jan)
Upper Respiratory Tract Infection Symptoms Coulehan JL, Eberhard S, Kapner L, Taylor F, Rogers K, Garry PVitamin C and acute illness in Navajo school children N Engl J Med. (1976 Oct 28)
Upper Respiratory Tract Infection Symptoms Peters EM, Goetzsche JM, Grobbelaar B, Noakes TDVitamin C supplementation reduces the incidence of postrace symptoms of upper respiratory tract infection in ultramarathon runners Am J Clin Nutr. (1993 Feb)
Upper Respiratory Tract Infection Risk Gormly PJMegadosage of ascorbic acid in an Antarctic expedition Br J Nutr. (1977 Mar)
Cortisol Pirbudak L, Balat O, Cekmen M, Ugur MG, Aygün S, Oner UEffect of ascorbic acid on surgical stress response in gynecologic surgery Int J Clin Pract. (2004 Oct)
Blood Flow Fernandes PR, Lira FA, Borba VV, Costa MJ, Trombeta IC, Santos Mdo S, Santos Ada CVitamin C restores blood pressure and vasodilator response during mental stress in obese children Arq Bras Cardiol. (2011 Jun)
Plasma Vitamin C Davison GW, Ashton T, George L, Young IS, McEneny J, Davies B, Jackson SK, Peters JR, Bailey DMMolecular detection of exercise induced free radicals following ascorbate prophylaxis in type 1 diabetes mellitus: a randomised controlled trial Diabetologia. (2008 Nov)
Oxidative Stress Biomarkers Van Hoydonck PG, Schouten EG, Manuel Y Keenoy B, van Campenhout A, Hoppenbrouwers KP, Temme EHDoes vitamin C supplementation influence the levels of circulating oxidized LDL, sICAM 1, sVCAM 1 and vWF antigen in healthy male smokers Eur J Clin Nutr. (2004 Dec)
Blood Flow Mullan BA, Ennis CN, Fee HJ, Young IS, McCance DRPretreatment with intravenous ascorbic acid preserves endothelial function during acute hyperglycaemia (R1) Clin Exp Pharmacol Physiol. (2005 May Jun)
Blood Flow Stamatelopoulos KS, Lekakis JP, Papamichael CM, Papaioannou TG, Cimboneriou A, Stamatelopoulos SFOral administration of ascorbic acid attenuates endothelial dysfunction after short term cigarette smoking Int J Vitam Nutr Res. (2003 Nov)
Blood glucose Pleiner J, Schaller G, Mittermayer F, Bayerle Eder M, Roden M, Wolzt MFFA induced endothelial dysfunction can be corrected by vitamin C J Clin Endocrinol Metab. (2002 Jun)
Pre Eclampsia Risk Kalpdev A, Saha SC, Dhawan VVitamin C and E supplementation does not reduce the risk of superimposed PE in pregnancy Hypertens Pregnancy. (2011)
Anti Oxidant Enzyme Profile Ruiz Ramos M, Vargas LA, Fortoul Van der Goes TI, Cervantes Sandoval A, Mendoza Nunez VMSupplementation of ascorbic acid and alpha tocopherol is useful to preventing bone loss linked to oxidative stress in elderly J Nutr Health Aging. (2010 Jun)
Bone Mineral Density Chuin A, Labonté M, Tessier D, Khalil A, Bobeuf F, Doyon CY, Rieth N, Dionne IJEffect of antioxidants combined to resistance training on BMD in elderly women: a pilot study Osteoporos Int. (2009 Jul)
Body Fat Knab AM, Shanely RA, Jin F, Austin MD, Sha W, Nieman DCQuercetin with vitamin C and niacin does not affect body mass or composition Appl Physiol Nutr Metab. (2011 Jun)
Bacterial Vaginosis Symptoms Petersen EE, Genet M, Caserini M, Palmieri REfficacy of vitamin C vaginal tablets in the treatment of bacterial vaginosis: a randomised, double blind, placebo controlled clinical trial Arzneimittelforschung. (2011)
Oxidative Stress Biomarkers Monika Lagowska Lenard, Zbigniew Stelmasiak, Halina Bartosik PsujekInfluence of vitamin C on markers of oxidative stress in the earliest period of ischemic stroke Pharmacol Rep. (Jul Aug 2010)
Upper Respiratory Tract Infection Risk Coulehan JL, Reisinger KS, Rogers KD, Bradley DWVitamin C prophylaxis in a boarding school N Engl J Med. (1974 Jan 3)
Depression Symptoms Brody SHigh dose ascorbic acid increases intercourse frequency and improves mood: a randomized controlled clinical trial Biol Psychiatry. (2002 Aug 15)
Cataract Risk Christen WG, Glynn RJ, Sesso HD, Kurth T, MacFadyen J, Bubes V, Buring JE, Manson JE, Gaziano JMAge related cataract in a randomized trial of vitamins E and C in men Arch Ophthalmol. (2010 Nov)
Triglycerides Kim MK, Sasaki S, Sasazuki S, Okubo S, Hayashi M, Tsugane SLong term vitamin C supplementation has no markedly favourable effect on serum lipids in middle aged Japanese subjects Br J Nutr. (2004 Jan)
Charcot Marie Tooth Disease Symptoms Pareyson D, Reilly MM, Schenone A, Fabrizi GM, Cavallaro T, Santoro L, Vita G, Quattrone A, Padua L, Gemignani F, Visioli F, Laurà M, Radice D, Calabrese D, Hughes RA, Solari A; CMT TRIAAL; CMT TRAUK groupsAscorbic acid in Charcot Marie Tooth disease type 1A (CMT TRIAAL and CMT TRAUK): a double blind randomised trial Lancet Neurol. (2011 Apr)
Uric Acid Han Yao Huang, Lawrence J Appel, Michael J Choi, Allan C Gelber, Jeanne Charleston, Edward P Norkus, Edgar R Miller 3rdThe effects of vitamin C supplementation on serum concentrations of uric acid: results of a randomized controlled trial Arthritis Rheum. (2005 Jun)
Uric Acid Xin Xin Liu, Xiao Xue Wang, Ling Ling CuiAssociation between Oral vitamin C supplementation and serum uric acid: A meta analysis of randomized controlled trials Complement Ther Med. (2021 Aug)
Total cholesterol de Oliveira IM, Hauschild DB, Machado RP, Marques BS, Wazlawik EOral vitamin C supplementation decreased low density lipoprotein in adults on hemodialysis: A systematic review and meta analysis. Nutr Res. (2025 Jul)
COVID 19 Severity Saeidreza JamaliMoghadamSiahkali, Besharat Zarezade, Sogol Koolaji, SeyedAhmad SeyedAlinaghi, Abolfazl Zendehdel, Mohammad Tabarestani, Ehsan Sekhavati Moghadam, Ladan Abbasian, Seyed Ali Dehghan Manshadi, Mohamadreza Salehi, Malihe Hasannezhad, Sara Ghaderkhani, Mohsen Meidani, Faeze Salahshour, Fatemeh Jafari, Navid Manafi, Fereshteh GhiasvandSafety and effectiveness of high dose vitamin C in patients with COVID 19: a randomized open label clinical trial Eur J Med Res. (2021 Feb 11)
COVID 19 Severity Suma Thomas, Divyang Patel, Barbara Bittel, Kathy Wolski, Qiuqing Wang, Anirudh Kumar, Zachary J IlGiovine, Reena Mehra, Carla McWilliams, Steve E Nissen, Milind Y DesaiEffect of High Dose Zinc and Ascorbic Acid Supplementation vs Usual Care on Symptom Length and Reduction Among Ambulatory Patients With SARS CoV 2 Infection: The COVID A to Z Randomized Clinical Trial JAMA Netw Open. (2021 Feb 1)
Weight Huck CJ, Johnston CS, Beezhold BL, Swan PDVitamin C status and perception of effort during exercise in obese adults adhering to a calorie reduced diet Nutrition. (2012 Jun 5)
Subjective Well Being Zhang M, Robitaille L, Eintracht S, Hoffer LJVitamin C provision improves mood in acutely hospitalized patients Nutrition. (2011 May)
Sperm Quality Vani K, Kurakula M, Syed R, Alharbi KClinical relevance of vitamin C among lead exposed infertile men Genet Test Mol Biomarkers. (2012 Sep)
Microcirculation Stewart JM, Ocon AJ, Medow MSAscorbate improves circulation in postural tachycardia syndrome Am J Physiol Heart Circ Physiol. (2011 Sep)
Upper Respiratory Tract Infection Symptoms Hunt C, Chakravorty NK, Annan G, Habibzadeh N, Schorah CJThe clinical effects of vitamin C supplementation in elderly hospitalised patients with acute respiratory infections Int J Vitam Nutr Res. (1994)
Preterm Birth Risk Hauth JC, Clifton RG, Roberts JM, Spong CY, Myatt L, Leveno KJ, Pearson GD, Varner MW, Thorp JM Jr, Mercer BM, Peaceman AM, Ramin SM, Sciscione A, Harper M, Tolosa JE, Saade G, Sorokin Y, Anderson GB; Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Maternal Fetal Medicine Units Network (MFMU)Vitamin C and E supplementation to prevent spontaneous preterm birth: a randomized controlled trial Obstet Gynecol. (2010 Sep)
Heart Rate Gomes ME, El Messaoudi S, Lenders JW, Bellersen L, Verheugt FW, Smits P, Tack CJHigh dose ascorbic acid does not reverse central sympathetic overactivity in chronic heart failure J Clin Pharm Ther. (2011 Oct)
Gout Symptoms Stephen P Juraschek, J Michael Gaziano, Robert J Glynn, Natalya Gomelskaya, Vadim Y Bubes, Julie E Buring, Robert H Shmerling, Howard D SessoEffects of vitamin C supplementation on gout risk: results from the physicians health study II trial Am J Clin Nutr. (2022 May 16)
All Cause Mortality Sharma Y, Sumanadasa S, Shahi R, Woodman R, Mangoni AA, Bihari S, Thompson CEfficacy and safety of vitamin C supplementation in the treatment of community acquired pneumonia: a systematic review and meta analysis with trial sequential analysis. Sci Rep. (2024 May 24)